Have a look at scenario the place there are 2 molecules of the identical
protein, which suggests identical major sequence. As well as they fold
on the identical time in the identical funnel. Every protein, which is
represented by a marble, is predicted to take a particular path because it
strikes down the funnel in the course of the folding course of. Whereas it folds,
it’s potential that the 2 proteins collide on the best way down the
funnel, and on account of this collision, one or each of these
proteins misfolds (kinds a kinetic lure). As with all collision,
power is exchanged between the colliding molecules, and we will
assume that the power modifications on account of the collision
contribute to potential misfolding. How can one characterize how
power modifications (thermodynamic state capabilities) within the funnel mannequin
as collision has to happen for each proteins to account for the
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